发明名称 |
MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA |
摘要 |
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap t he -OH group at the 3'-position of the deoxyribose. |
申请公布号 |
CA2425112(A1) |
申请公布日期 |
2002.04.11 |
申请号 |
CA20012425112 |
申请日期 |
2001.10.05 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY |
发明人 |
ITAGAKI, YASUHIRO;LI, ZENGMIN;JU, JINGYUE;EDWARDS, JOHN ROBERT |
分类号 |
G01N33/53;C07B61/00;C07H19/10;C07H19/20;C07H21/00;C12N15/09;C12Q1/68;G01N37/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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