PERILIPIN AS A TARGET FOR REGULATION OF BODY WEIGHT, MUSCLE MASS AND DIABETES

摘要

The present invention relates to screening assays to identify compounds that modulate the activity or expression of perilipin. The present invention also relates to methods and therapeutic compositions for the prevention or treatment of body weight disorders or diabetes comprising administering to subjects compounds that modulate the activity or expression of perilipin. In one aspect, the invention of perilipin in order to treat and/or prevent obesity or diabetes, and to enhance lipid metabolism and muscle mass. In another aspect, the invention relates to methods and compositions that agoni ze the activity of perilipin in order to enhance lipid accumulation in a subjec t in order to increase weight gain.