PROCESS FOR THE FERMENTATIVE PREPARATION OF D-PANTOTHENIC ACID USING CORYNEFORM BACTERIA

摘要

The invention relates to a process for the preparation of D-pantothenic acid by fermentation of coryneform bacteria, in which bacteria in which the nucleotide sequence which codes for pyruvate oxidase (EC 1.2.2.2) (poxB gene) is attenuated are employed, the following steps being carried out: a) fermentation of D-pantothenic acid-producing bacteria in which at least the gene which codes for pyruvate oxidase is attenuated. b) concentration of the D-pantothenic acid in the medium or in the cells of the bacteria; and c) isolation of the D-pantothenic acid produced.