32146 AND 57259, NOVEL HUMAN TRANSPORTERS AND USES THEREOF

摘要

The invention provides isolated nucleic acids molecules, designated TFM-2 and TFM-3 nucleic acid molecules, which encode novel transporter family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TFM-2 and/or TFM-3 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TFM-2 and/or TFM-3 gene has been introduced or disrupted. The invention still further provides isolated TFM-2 and TFM-3 polypeptides, fusion polypeptides, antigenic peptides and anti-TFM-2 and anti-TFM-3 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.