PROCESS TO PREPARE SULFONAMIDES

摘要

A process for the preparation of a sulfonamide of formula (II), comprising reacting at elevated temperature an aniline of formula (I), with a sulfonating agent A of the formula R<1>-SO2-Z in the presence of a catalytic amount of either: (i) an amide B-1, other than N,N-dimethylformamide, or (ii) a high boiling tertiary amine B-2. Also provided in accordance with the present invention are processes for preparing sulfonamides of formula (II) by reacting an aniline of formula (I) with sulfanating agent A of the formula R<1>-SO2-Z in the presence of N,N-dimethylformamide, at a temperature in the range of about 120 DEG C to about 160 DEG C for about three to about seven hours. X, Y, Z, R and R<1> are as defined herein.