发明名称 |
Synthetic glycosulfopeptides and methods of synthesis thereof |
摘要 |
A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisx group or a sialyl Lewisa group. In a preferred version the GSPs have an O-glycan comprising a beta1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
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申请公布号 |
US2002042102(A1) |
申请公布日期 |
2002.04.11 |
申请号 |
US20010849562 |
申请日期 |
2001.05.04 |
申请人 |
CUMMINGS RICHARD D.;MCEVER RODGER P. |
发明人 |
CUMMINGS RICHARD D.;MCEVER RODGER P. |
分类号 |
A61K38/00;C07H3/06;C07K5/00;C07K7/00;C07K14/705;C12N15/56;(IPC1-7):C12P21/02;C07K9/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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