GENE RELATING TO DRUG TOLERANCE AND UTILIZATION THEREOF

摘要

By using an anticancer agent having a unique structure which is never been reported as being transported by a known transporter protein capable of imparting tolerance to cancer cells, a cell line tolerant to this anticancer agent is established. Then a cDNA encoding a protein which is expressed at a high level in this tolerant strain is successfully isolated. Use of this gene together with the an anticancer agent and to select an anticancer agent which can be administered to patients with cancer. Moreover, a candidate compound for an inhibitor of the transporter can be screened thereby. By using a combination of the inhibitor thus obtained with the above-described anticancer agent, the sensitivity of cancer cells tolerant to the anticancer agent can be enhanced.