发明名称 |
BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS |
摘要 |
The present invention relates to compounds of the formula (I) wherein R1 and R2 are each independently lower alkyl, lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto, sulfo, hydrogen, halogen, nitro, cyano or hydroxy, or may form a ring structure; Q<1> is N or CH; L is optionally substituted unsaturated 3 to 10-membered heterocyclic group; X is optionally substituted monocyclic arylene or monocyclic heteroarylene; Y is -(A<1>)m-(A<2>)n-(A<4>)k-; Z is direct bond, -CH2-, -NH- or -O-; and R is hydrogen or lower alkyl, or a salt thereof. The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
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申请公布号 |
WO0228835(A1) |
申请公布日期 |
2002.04.11 |
申请号 |
WO2001JP08581 |
申请日期 |
2001.09.28 |
申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD.;DAISO CO., LTD.;TAKASUGI, HISASHI;TERASAWA, TAKESHI;INOUE, YOSHIKAZU;NAKAMURA, HIDEKO;NAGAYOSHI, AKIRA;OHTAKE, HIROAKI;FURUKAWA, YOSHIRO;MIKAMI, MASAFUMI;HINOUE, KAZUMASA;OHTSUBO, MAKOTO |
发明人 |
TAKASUGI, HISASHI;TERASAWA, TAKESHI;INOUE, YOSHIKAZU;NAKAMURA, HIDEKO;NAGAYOSHI, AKIRA;OHTAKE, HIROAKI;FURUKAWA, YOSHIRO;MIKAMI, MASAFUMI;HINOUE, KAZUMASA;OHTSUBO, MAKOTO |
分类号 |
A61K31/426;A61K31/4422;A61K31/4427;A61K31/4965;A61P1/18;A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P43/00;C07D213/30;C07D213/38;C07D213/40;C07D213/56;C07D213/73;C07D213/74;C07D213/81;C07D241/12;C07D277/28;C07D277/30;C07D277/40;(IPC1-7):C07D213/40;A61K31/442;A61K31/44 |
主分类号 |
A61K31/426 |
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