发明名称 |
STABILISATION OF PLASMID INHERITANCE IN BACTERIA BY PREVENTING MULTIMERISATION |
摘要 |
The invention relates to a vaccine comprising a pharmaceutically acceptable carrier or diluent and a bacterium, wherein the bacterium contains (i) a DNA sequence encoding a site-specific recombinase, and (ii) a plasmid comprising a recognition element for the recombinase and a DNA sequence encoding a heterologous polypeptide. The recombinase stabilises inheritance of the plasmid and thereby prevents the bacterium from losing the ability to expres s the heterologous polypeptide.
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申请公布号 |
CA2423307(A1) |
申请公布日期 |
2002.04.11 |
申请号 |
CA20012423307 |
申请日期 |
2001.10.02 |
申请人 |
ACAMBIS RESEARCH LIMITED |
发明人 |
TURNER, ARTHUR KEITH;STEPHENS, JONATHAN CLIVE |
分类号 |
A61K39/00;A61K39/04;A61K39/07;A61K39/095;A61K39/10;A61K39/106;A61K39/108;A61K39/112;A61P1/04;A61P31/04;A61P37/02;C12N1/21;C12N15/68;(IPC1-7):A61K39/02;C12N15/63 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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