HUMAN G-PROTEIN COUPLED RECEPTOR AND USES THEREOF

摘要

The present invention relates to the IGS43 G-protein coupled receptor family, and to polynucleotides encoding said IGS43 proteins. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides, to a vector containing said polynucleotides, a host cell containing such vector and non-human transgenic animals where the IGS43-gene is either overexpressed, misexpressed, underexpressed or suppressed (knock-out animals). The invention further relates to a method for screening compounds capable to act as an agonist or an antagonist of said G-protein coupled receptor family IGS43 and the use of IGS43 polypeptides and polynucleotides and agonists or antagonists to the IGS43 receptor family in the treatment of a broad range of disorders and diagnostic assays for such conditions. The invention in particular relates to a method for screening compounds capable to act as an agonist or an antagonist of said G-protein coupled receptor family IGS43 and the use of IGS43 polypeptides and polynucleotides and agonists or antagonists to the IGS43 receptor family in the treatment of dysfunctions, disorders, or diseases related to uterus, kidney, lung, trachea, colon, small intestine, stomach, mammary gland, prostate, testis, central nervous system, cerebellum, and spinal cord, and diagnostic assays for such conditions.