TARGETING MOLECULES FOR ADENOVIRAL VECTORS

摘要

The present invention relates to targeting molecules which are useful to specifically target an adenoviral particle to a desired cell type. These targeting molecules comprise a soluble adenoviral receptor domain, a trimerization domain, and a targeting ligand domain. Further provided are polynucleotides encoding such targeting molecule, expression vectors includi ng such polynucleotides, and methods to target an adenoviral particle to a cell , as well as methods to deliver a heterologous gene selectively to a cell.