HUMAN ANTI-CD40 ANTIBODIES

摘要

Human antibodies capable of binding CD40 are disclosed, wherein the antibodi es act as antagonists of CD40-directed activities of B cells, but have no or minimal ability to induce B cell proliferation. The antibodies are useful fo r treating diseases mediated by CD40-expressing cells, such as those diseases characterized by B cell activation, as well as cancer of B-cell lineage, including Non-Hodgkin's Lymphoma.