| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new imidazothiazole derivative and a medicine having metabotropic glutamate receptor (hereinafter referred to mGluR) actions and more particularly specifically acting on the mGluR1 and useful as a prophylactic and therapeutic agent for cerebral infarction. SOLUTION: This imidazothiazole derivative is represented by the following general formula (1) (wherein, R1 and R2 are each the same or different and H, a lower alkyl or a cycloalkyl; R3 is H or a lower alkyl; R4 and R5 are each the same or different and H, a halogen, nitro, a substitutable lower alkyl, a substitutable aryl, a substitutable heteroaryl, C(=O)-R9, an NH-C(=O)-O-lower alkyl or the like; and X is oxygen or H). The medicine comprises the imidazothiazole derivative as an active ingredient.
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