PHARMACEUTICAL COMPOSITION WITH FUNGICIDE ACTIVITY AND DERIVATIVES OF DIPEPTIDE OF ALPHA-AMINO ACID OR ITS DERIVATIVE AND CYCLOPENTANE-BETA-AMINO ACID OR ITS DERIVATIVE

摘要

organic chemistry, amino acids, pharmacy. SUBSTANCE: invention relates to the composition with antifungal activity containing at least one cyclopentane-beta-amino acid and/or its derivative of the general formula (Ib) where R1 and R2 in common mean residue of the formula =CH2; R6 and Y mean hydrogen atom and at least one alpha-amino acid and/or its derivative of the formula (Ia) additionally where R3 means linear or branched C1-C8-alkyl; R4 and R5 means hydrogen X means hydroxyl and alpha-amino acid and/or its derivative and cyclopentane-beta- amino acid and/or its derivative are taken in the molar ratio from 1: 1 to 1:5. Invention relates to also dipeptide of the general formula (A) where R1-R6 are given above; X and Y mean a moiety of covalent bond of alpha-amino acid and cyclopentane-beta-amino acid. Invention relates to also a pharmaceutical composition with antifungal activity containing at least one dipeptide of the formula (A) as an active substance taken in effective amount and nontoxic pharmaceutically inert carrier. EFFECT: valuable antifungal properties of composition. 4 cl, 1 tbl, 7 ex