INTERMEDIATE COMPOUND FOR PRODUCING DIACYL-SUBSTITUTED GUANIDINE

摘要

PROBLEM TO BE SOLVED: To provide an intermediate compound for producing a diacyl- substituted guanidine useful as a Na+/H+ exchange inhibitor. SOLUTION: This intermediate compound is a compound of the formula III [wherein, X(2) is a group as shown in the formula (a)]. As an example of the compound of the formula III, 4-isopropyl-3-methylsulfonylbenzoylguanidine and 4-fluoro-3-trifluoromethylbenzoylguanidine are cited. As the method for producing them, a method of reacting an acid chloride of a corresponding benzoic acid with guanidine hydrochloride in the presence of a base is exemplified. The diacylguanidine used as a medicine is obtained by reacting the compound of the formula III with a prescribed benzoic acid derivative.