| 摘要 |
The present invention describes methods for synthesizing novel dithiolane derivatives, ligands with high affinity for the nuclear hormone receptors, peroxisome proliferator-activated receptor-gamma (PPARgamma) and/or PPARalpha. Methods for using these compounds in the treatment of endocrine, skin, cardiovascular, immunological, neurological, neuropsychiatric, neoplastic and chronic viral diseases of various organs, including the eye are described. Methods of treating proliferative and inflammatory diseases, degenerative diseases, and age-related dysregulations, caused by an hereditary (genetic) condition or an environmental insult are also provided. In addition, methods are provided for treating conditions and diseases comprising the step of administering to a human or an animal in need thereof a therapeutic amount of pharmacological compositions comprising a pharmaceutically acceptable carrier, a PPARalpha agonist, and a second agent selected from the following: a PPARgamma ligand, or an RXR ligand (rexinoid), or a PPARgamma/RXR ligand, effective to reverse, slow, stop, or prevent the pathological inflammatory or degenerative process.
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