发明名称 |
Treatment of ischemic brain injuries with brain targeted anti oxidant compounds |
摘要 |
A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.
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申请公布号 |
US6369106(B1) |
申请公布日期 |
2002.04.09 |
申请号 |
US19990472033 |
申请日期 |
1999.12.27 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM;MOR-RESEARCH APPLICATIONS LTD.;RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. |
发明人 |
ATLAS DAPHNE;MELAMED ELDAD;OFFEN DANIEL |
分类号 |
A61K31/00;A61K31/16;A61K31/198;A61K31/216;A61K31/223;A61K38/00;A61K38/05;A61K38/06;C07C323/59;C07K5/02;(IPC1-7):A61K31/225;A61K31/22;A61K31/195 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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