Antibodies to alphavbeta3 integrin

摘要

The invention relates to monoclonal antibodies to the alphavbeta3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on alphavbeta3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.