发明名称 |
Drug complex for treatment of metastatic prostate cancer |
摘要 |
A drug complex for delivery of a drug or other agent to a target cell, comprising a targeting carrier molecule which is selectively distributed to a specific cell type or tissue containing the specific cell type; a linker which is acted upon by a molecule which is present at an effective concentration in the environs of the specific cell type; and a drug or an agent to be delivered to the specific cell type. In particular, a drug complex for delivering a cytotoxic drug to prostate cancer cells, comprising a targeting carrier molecule which is selectively delivered to prostate tissue, bone or both; a peptide which is a substrate for prostate specific antigen; and a cytotoxic drug which is toxic to androgen independent prostate cancer cells.
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申请公布号 |
US6368598(B1) |
申请公布日期 |
2002.04.09 |
申请号 |
US19980110822 |
申请日期 |
1998.07.06 |
申请人 |
JCRT RADIATION ONCOLOGY SUPPORT SERVICES, INC.;UNIV NORTHEASTERN;BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
D'AMICO ANTHONY V.;BUBLEY GLENN J.;JEBARATNAM DAVID J.;WEINBERG JAMES S. |
分类号 |
A61K38/06;A61K38/08;A61K38/14;A61K38/16;A61K39/395;A61K47/48;A61P35/04;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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