发明名称 |
Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells |
摘要 |
This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
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申请公布号 |
US6368596(B1) |
申请公布日期 |
2002.04.09 |
申请号 |
US19980112041 |
申请日期 |
1998.07.08 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GHETIE MARIA-ANA;UHR JONATHAN W.;VITETTA ELLEN S. |
分类号 |
A61K38/00;A61K47/48;C07K16/00;C07K16/28;C07K16/32;G01N33/574;(IPC1-7):A61K39/395;A61K39/40;A61K39/42 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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