发明名称 |
Method for inhibiting gene expression promoted by AP1 protein with RARbeta selective retinoids and method for treatment of diseases and conditions with such retinoids |
摘要 |
Retinoid compounds which repress expression of the gene promoted by AP1 protein but which do not significantly activate expression of the genes having RA-responsive elements in their promoter region through RARalpha and RAR&Ggr; receptor subtypes, are used, with reduced side effects, for treating diseases and conditions which are responsive to therapy with retinoids.
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申请公布号 |
US6369100(B1) |
申请公布日期 |
2002.04.09 |
申请号 |
US20000482589 |
申请日期 |
2000.01.13 |
申请人 |
ALLERGAN SALES, INC. |
发明人 |
NAGPAL SUNIL;SONG TAE K.;VULIGONDA VIDYASAGAR;ATHANIKAR JYOTI;CHANDRARATNA ROSHANTHA A. |
分类号 |
C07D309/12;A61K31/35;A61K31/351;A61K31/443;A61K31/455;A61P9/10;A61P17/00;A61P35/02;A61P43/00;C07D405/12;(IPC1-7):A61K43/12;A61K31/44 |
主分类号 |
C07D309/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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