发明名称 |
Antibodies against CTLA4 and uses therefor |
摘要 |
The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.
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申请公布号 |
US2002039581(A1) |
申请公布日期 |
2002.04.04 |
申请号 |
US20010772103 |
申请日期 |
2001.01.26 |
申请人 |
CARRENO BEATRIZ M.;WOOD CLIVE;TURNER KATHERINE;COLLINS MARY;GRAY GARY S.;MORRIS DONNA;O'HARA DENISE;HINTON PAUL R.;TSURUSHITA NAOYA |
发明人 |
CARRENO BEATRIZ M.;WOOD CLIVE;TURNER KATHERINE;COLLINS MARY;GRAY GARY S.;MORRIS DONNA;O'HARA DENISE;HINTON PAUL R.;TSURUSHITA NAOYA |
分类号 |
C12N15/02;A61K39/395;A61K47/48;A61K51/10;A61P37/06;A61P37/08;C07K16/18;C07K16/28;C12P21/08;(IPC1-7):A61K39/395;C07K16/46 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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