| 摘要 |
<p>The invention is directed to methods to inhibit p38- alpha kinase using compounds of formula (1), and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein (a) represents a single or double bond; one Z<2> is CA or CR<8>A and the other is CR<1>, CR<1>2, NR<6> or N wherein each R<1>, R<6> and R<8> is independently hydrogen or noninterfering substituent; A is -Wi-COXjY wherein Y is COR<2> or an isostere thereof and R<2> is hydrogen or a noninterfering substituent, each of W and X is a spacer of 2-6 ANGSTROM , and each of i and j is independently 0 or 1; Z<3> is NR<7> or O; each R<3> is independently a noninterfering substituent; n is 0-3; each of L<1> and L<2> is a linker; each R<4> is independently a noninterfering substituent; m is 0-4; Z<1> is CR<5> or N wherein R<5> is hydrogen or a noninterfering substituent; each of l and k is an integer from 0-2 wherein the sum of l and k is 0-3; Ar is an aryl group substituted with 0-5 noninterfering substituents, wherein two noninterfering substituents can form a fused ring; and the distance between the atom of Ar linked to L<2> and the center of the alpha ring is 4.5-24 ANGSTROM .</p> |
