ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR-B (VEGF-B) IN DEVELOPING BONES AND USES THEREOF

摘要

This invention relates to the expression of VEGF-B in developing bones. Methods are provided for stimulating angiogenesis of a bone, for stimulating the healing of bone fractures or breaks, for enhancing the acceptance and/or securing of an implant to a bone and for the treatment or alleviation of the inflammation of the epiphysis of a long bone as well as the use of a pharmaceutical composition which comprises a polypeptide having an amino acid sequence of at least 85 % sequence identity with the sequence of SEQ ID NO: 2 or 4, or fragment thereof having the biological activity of VEGF-B to stimulate angiogenesis of a bone.