POLYMERIC MICELLE CONTAINING CISPLATIN ENCLOSED THEREIN AND USE THEREOF
摘要
A complex comprising cisplatin and a poly(ethylene glycol)/poly(glutamic acid) block copolymer, wherein the cisplatin is enclosed in the copolymer through ligand displacement in which a carboxyl anion of the copolymer is replaced with a chlorine ion of the cisplatin. This complex can give a medicine reduced in toxicity and usable by a new method of administration.
申请公布号
WO0226241(A1)
申请公布日期
2002.04.04
申请号
WO2001JP08337
申请日期
2001.09.26
申请人
CENTER FOR ADVANCED SCIENCE AND TECHNOLOGY INCUBATION, LTD.;KATAOKA, KAZUNORI;NISHIYAMA, NOBUHIRO;YOKOYAMA, MASAYUKI;OKANO, TERUO