SOLUBILISED PROTEIN VACCINES

摘要

The invention relates to pharmaceutical vaccine compositions for treating or alleviating self-protein-mediated inflammatory pathologies, such as rheumatoid arthritis, Crohn's disease, inflammatory bowel disease, which vaccine compositions comprise a modified immunogenic self-protein and a surfactant capable of acting as a solubiliser. Compositions of modified human TNFalpha and cetylpyridinium chloride are provided.