发明名称 |
Methods for stimulation of synthesis of synaptophysin in the central nervous system |
摘要 |
A method of increasing the synthesis and/or secretion of synaptophysin comprises administering to a patient with a neurological disease or a patient at risk of developing a neurological disease an effective quantity of a purine derivative or analogue, a tetrahydroindolone derivative or analogue, or a pyrimidine derivative or analogue. If the compound is a purine derivative, the purine moiety can be guanine or hypoxanthine. The neurological disease can be a neurodegenerative disease such as Alzheimer's disease or a neurodevelopmental disorder such as Down's syndrome. Typically, the compound can pass through the blood-brain barrier. The purine moiety can be hypoxanthine or guanine. A particularly preferred purine derivative is N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide.
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申请公布号 |
US2002040032(A1) |
申请公布日期 |
2002.04.04 |
申请号 |
US20010899478 |
申请日期 |
2001.07.05 |
申请人 |
GLASKY MICHELLE S.;LAHIRI DEBOMOY K.;FARLOW MARTIN R. |
发明人 |
GLASKY MICHELLE S.;LAHIRI DEBOMOY K.;FARLOW MARTIN R. |
分类号 |
A61K31/505;A61K31/522;C07D473/00;(IPC1-7):A61K31/522;A61K31/404 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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