发明名称 |
METHOD FOR APPLYING NMR FOR LIGAND DISCOVERY OR AS A DRUG SCREENING TOOL |
摘要 |
<p>The present invention relates to a method for screening compounds to identify compounds that bind to a specific target, comprising the steps of: (a) providing a target immobilized to a solid support; (b) generating a first NMR spectrum of the said compounds to be screened in the presence of the solid support without the target molecule immobilized thereto; (c) generating a second NMR spectrum of the said compounds to be screened in the presence of the solid support with the target molecule immobilized thereto; and (d) comparing said first and second NMR spectrum to determine differences between said first and second NMR spectrum. Further the invention relates to an NMR apparatus having arranged therein a particular NMR probe.</p> |
申请公布号 |
WO0227309(A1) |
申请公布日期 |
2002.04.04 |
申请号 |
WO2001NL00711 |
申请日期 |
2001.09.27 |
申请人 |
UNIVERSITEIT LEIDEN;SIEGAL, GREGG, DAVID |
发明人 |
SIEGAL, GREGG, DAVID |
分类号 |
G01N24/08;G01R33/30;G01R33/46;G01R33/465;(IPC1-7):G01N24/08;G01N33/50 |
主分类号 |
G01N24/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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