CHEMICAL REAGENTS FOR FORMATION OF DISULFIDE BONDS IN PEPTIDES

摘要

The invention pertains to the discovery of a class of reagents that effectively form intramolecular disulfide bonds in peptides. Intermolecular disulfide linkage formation is low or essentially non-existent. In addition, preferred reagents of this invention are relatively mild and do not oxidize "vulnerable" residues in the subject peptide(s). In addition the reagents and reaction products are safe end essentially non-toxic. One particularly preferred reagents is [Pt(en)2Cl2]2+ where en is ethylenediamine.