56115, A NOVEL HUMAN TWIK POTASSIUM CHANNEL AND USES THEREFOR

摘要

The invention provides isolated nucleic acid molecules, designated TWIK-9 nucleic acid molecules, which encode novel TWIK-related potassium channel subunit molecules. The innovation also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK-9 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK-9 gene has been introduced or disrupted. The invention still further provides isolated TWIK-9 proteins, fusion proteins, antigenic peptides and anti-TWIK-9 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.