CATECHOLAMINE PHARMACEUTICAL COMPOSITIONS AND METHODS

摘要

Pharmaceutical compositions comprising, and methods using, adrenergic compounds and complement compounds. Embodiments include compositions comprising 1 subefficacious amount of an adrenergic compounds; and a safe and effective amount of a complement to said adrenergic compound. Other embodiments include compositions comprising: (a) a safe and effective amount of an adrenergic compound; and (b) a complement to said adrenergic compound, selected from the group consisting of a hyperpreserving amount of an ascorbate, a safe and effective amount of an opioid, a hyperpreserving amount of a polycarboxylic acid chelater, a safe and effective amount of D-ribose and adenosine derivatives, and mixture thereof. Methods are also provided for regulating an adrenergic receptor in a human or other animal, comprising the administration of: (c) a low dose of an adrenergic compound; and (d) a safe and effective amount of a complement to said adrenergic compound. Preferably, the adrenergic compound is a catecholamine. Preferred complements include ascorbates, particularly ascorbic acid. Methods include the treatment of neurological disorders, hypotension, forward failure, backward failure, congestive heart failure, shock, hypertension, hemmorhage, disorders associated with anesthesia, chronic obstructive pulmonary disease, asthma, colic, Crohn's disease, anaphylaxis, interstitial cystitis, overactive bladder syndrome, premature labor, myethsenia gravis, and glaucoma.