| 发明名称 |
METHODS FOR INHIBITING BRAIN TUMOR GROWTH BY USING SELECTED INTEGRIN ANTAGONISTS |
| 摘要 |
<p>The present invention describes methods for inhibition of tumor growth in the brain, using antagonists of integrins such as alphavbeta3 and alphavbeta5. Antagonists of the present invention can inhibit angiogenesis in brain tumor tissue. They can also inhibit vitronectin and tenascin-mediated cell adhesion and migration in brain tumor cells. They can further induce direct brain tumor cell death.</p> |
| 申请公布号 |
SK10622001(A3) |
申请公布日期 |
2002.04.04 |
| 申请号 |
SK20010001062 |
申请日期 |
2000.01.26 |
| 申请人 |
CHILDRENS HOSPITAL LOS ANGELES |
发明人 |
LAUG WALTER E. |
| 分类号 |
A61K45/00;A61K38/00;A61K38/39;A61K39/395;A61P35/00;A61P43/00;C07K14/47;C07K16/18;C07K16/28;(IPC1-7):A61K39/00 |
主分类号 |
A61K45/00 |
| 代理机构 |
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