发明名称 |
Caenorhabditis elegans chemosensory bioassay for seven transmembrane receptor ligands |
摘要 |
<p>This invention relates to methods for producing a transgenic C. elegans that expresses a human 7TMR pan-neuronally, such that said transgenic C. elegans exhibits a known phenotype. These transgenic C. elegans can be used in a variety of ways, including, but not limited to: (1) screening and identifying substances that bind to and activate particular human 7TMRs; (2) screening for substances that antagonize human 7TMR activation; (3) identifying human 7TMRs that may respond to particular substances; and (4) evaluating the specificity and efficacy of substances on human 7TMR activation.</p> |
申请公布号 |
EP1192856(A2) |
申请公布日期 |
2002.04.03 |
申请号 |
EP20010203705 |
申请日期 |
2001.09.28 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
LIVI, GEORGE;SHELTON, CHRISTOPHER |
分类号 |
A01K67/033;G01N33/50;(IPC1-7):A01K67/033;C12N15/85 |
主分类号 |
A01K67/033 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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