AMINOBENZOIC ACID DERIVATIVES

摘要

Aminobenzoic acid derivatives represented by Formula (1) as follows: <CHEM> (wherein, R<1> represents a hydrogen atom, a C1-6 alkyl group, or the like; R<2> represents a hydrogen atom, a C1-6 alkyl group, or the like; R<3> represents a C8-25 alkyl group, or the like; R<4> represents a hydrogen atom or a group represented by OR<9> or CO2R<10> (wherein R<9> and R<10> represent a hydrogen atom or a C1-6 alkyl group); A represents a group represented by S(O)qR<15> (wherein q is 0, 1, or 2, R<15> represents a C1-6 alkyl group, a phenyl C1-3 alkyl group, or a group represented by (CH2)mOR<16> (wherein m is 2 or 3, and R<16> represents a hydrogen atom or a methoxymethyl group), or the like; X represents O, a single bond, CH=CH, or a group represented by NR<27> (wherein R<27> represents a hydrogen atom or a t-butoxycarbonyl group); Y represents O, CONH, NHCO, or a group represented by NR<28> (wherein R<28> represents a hydrogen atom or a t-butoxycarbonyl group); and n is an integer of 0 to 15) or pharmaceutically acceptable salts of the same are employed as VEGF receptor antagonists, and in particular as therapeutic agents for the diseases in which VEGF is involved.