| 摘要 |
The present invention relates to the use of a compound of formula I: in which, A<SUB>1 </SUB>is the radical corresponding to D- or L-Ser, A<SUB>2 </SUB>is the radical corresponding to D- or L-Asp or Glu, A<SUB>3 </SUB>is the radical corresponding to D- or L-Lys, Arg or Gm, A<SUB>4 </SUB>is the radical corresponding to D- or L-Pro, R<SUB>1 </SUB>and R<SUB>2 </SUB>are chosen, independently, from H, C<SUB>1</SUB>-C<SUB>12</SUB>-alkyl which may or may not be substituted, C<SUB>7</SUB>-C<SUB>20</SUB>-arylalkyl which may or may not be substituted, R<SUB>4</SUB>CO or R<SUB>4</SUB>COO, R<SUB>4 </SUB>being C<SUB>1</SUB>-C<SUB>12</SUB>-alkyl which may or may not be substituted, or C<SUB>7</SUB>-C<SUB>20</SUB>-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH<SUB>2 </SUB>or COOH, X<SUB>1 </SUB>and X<SUB>2 </SUB>are peptide or pseudopeptide bonds, X<SUB>3 </SUB>is CO or CH<SUB>2 </SUB>and R<SUB>3 </SUB>is OH, NH<SUB>2</SUB>, C<SUB>1</SUB>-C<SUB>1</SUB>-alkoxy or NH-X<SUB>4</SUB>-CH<SUB>2</SUB>-Z, X<SUB>4 </SUB>is a normal or branched C<SUB>1</SUB>-C<SUB>12 </SUB>hydrocarbon, and Z is H, OH, CO<SUB>2</SUB>H or CONH<SUB>2</SUB>, or the corresponding tripeptides comprising the radicals A<SUB>1</SUB>, A<SUB>2</SUB>, A<SUB>3</SUB>, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benefit from stimulation of angiogenesis. |
