| 发明名称 |
Pyridinone and pyridinethione derivatives having HIV inhibiting properties |
| 摘要 |
The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C<SUB>1-6 </SUB>alkyl or C<SUB>2-6 </SUB>alkenyl; X is (a-2) with q and r being O and Z being O, S or SO; R<SUB>1 </SUB>is aryl; R<SUB>2 </SUB>is selected from formyl; C<SUB>1-6</SUB>alkyloxycarbonylalkyl; Het<SUP>2</SUP>; Het<SUP>2</SUP>C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkylthio; C<SUB>1-6</SUB>alkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; R<SUB>3 </SUB>is selected from formyl; C<SUB>1-6</SUB>alkyl optionally substituted with one or two C<SUB>1-6</SUB>alkyloxy; R<SUB>4 </SUB>is hydrogen, with HTV inhibiting properties |
| 申请公布号 |
AU1259802(A) |
申请公布日期 |
2002.04.02 |
| 申请号 |
AU20020012598 |
申请日期 |
2001.09.18 |
| 申请人 |
JANSSEN PHARMACEUTICA N.V.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);INSTITUT CURIE |
发明人 |
JEROME GUILLEMONT;ABDELLAH BENJAHAD;DOMINIQUE MABIRE;CHI HUNG NGUYEN;DAVID GRIERSON;CLAUDE MONNERET;EMILE BISAGNI;GERARD SANZ;LAURENCE DECRANE |
| 分类号 |
A61K31/428;A61K31/4365;A61K31/4412;A61K31/443;A61K31/4439;A61K31/444;A61K31/453;A61K31/454;A61K31/4545;A61K31/47;A61K31/4709;A61K31/496;A61K31/497;A61K31/506;A61K31/5377;A61K31/541;A61K31/675;A61K45/00;A61P31/18;C07D213/64;C07D213/69;C07D213/70;C07D213/71;C07D213/75;C07D213/78;C07D213/80;C07D213/81;C07D213/82;C07D213/84;C07D213/85;C07D213/89;C07D215/22;C07D215/227;C07D215/36;C07D221/04;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D405/04;C07D405/06;C07D405/12;C07D405/14;C07D407/04;C07D407/06;C07D407/12;C07D407/14;C07D409/04;C07D409/12;C07D413/06;C07D413/12;C07D413/14;C07D417/06;C07D417/12;C07D471/04;C07D491/04;C07D495/04;C07F9/59;C07F9/6584 |
主分类号 |
A61K31/428 |
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