发明名称 |
Screening systems and methods for identifying modulators of xenobiotic metabolism |
摘要 |
The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity. |
申请公布号 |
AU9119201(A) |
申请公布日期 |
2002.04.02 |
申请号 |
AU20010091192 |
申请日期 |
2001.09.21 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
DAVID D MOORE;PING WEI;STEVEN S. CHUA |
分类号 |
A01K67/027;A61K49/00;C07K14/72;C12N15/09;C12N15/85;C12Q1/02;C12Q1/34;C12Q1/68;G01N33/15;G01N33/48;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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