Biotechnological process for preparing hydroxylated ML-236B derivatives, known as M-4 and M-4', and analogues thereof

摘要

The very effective conversion of ML-236B substances and derivatives thereof into 6'-hydroxylated products with the microorganisms of species Amycolatopsis orientalis, or with an extract or a hydroxylation-effective enzyme derived from said microorganism, is described. The products obtained are suitable as HMG-CoA reductase inhibitors or intermediates thereof. Thus, the products can be used, for example, as an antihypercholesterolemic in pharmacy.