发明名称 |
PEPTIDE NUCLEIC ACID DERIVATIVES WITH A NEGATIVE CHARGE, AGENTS AND METHODS FOR PRODUCING THEM |
摘要 |
The invention relates to PNA derivatives which carry a phosphoryl radical on the N terminus of the PNA backbone, for example a phosphate or a substituted phosphoryl radical, substituted phosphoryl derives optionally carrying one or more marker groups or groups for cross-linking or groups which favor intracellular take-up or groups which increase the binding affinity of the PNA derivative to nucleic acids. The invention also relates to a method for producing the aforementioned PNA derivatives and to their use as medicaments and diagnostic agents. |
申请公布号 |
WO0179249(A3) |
申请公布日期 |
2002.03.28 |
申请号 |
WO2001EP04027 |
申请日期 |
2001.04.07 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
UHLMANN, EUGEN;BREIPOHL, GERHARD;WILL, DAVID, WILLIAM |
分类号 |
G01N33/53;A61K48/00;A61P9/00;A61P11/06;A61P17/00;A61P17/06;A61P31/12;A61P35/00;A61P43/00;C07F9/09;C07F9/24;C07F9/547;C07H21/00;C08G69/48;C12N15/09;C12Q1/68;G01N30/88;G01N33/566 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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