PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK- beta ) INHIBITING ACTIVITY

摘要

Pyridine compounds of general formula (I) wherein -R<1> represents, or in which R<11> is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or -O-(CH2)n-R<111> ; R<2> represents hydrogen or halogen; R<3> represents hydrogen, -CR<31>R<32>R<33>, or -NR<34>R<35>; R<4> is hydrogen, carbamoyl, CN, carboxyl, etc.; R<5> is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.