发明名称 |
Enamine derivatives |
摘要 |
Enamine derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which Ar1 is an aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an arylene or heteroarylene group and Alk is a chain -CH2-CH(R)-, -CH=C(R)- or in which R is a carboxylic acid or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(Rw) group; Rx is a oxo, thioxo, or imino group; Rw and Rz is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.
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申请公布号 |
US2002037909(A1) |
申请公布日期 |
2002.03.28 |
申请号 |
US20010835656 |
申请日期 |
2001.04.16 |
申请人 |
NORMAN TIMOTHY JOHN;PORTER JOHN ROBERT;HUTCHINSON BRIAN WOODSIDE;RATCLIFFE ANDREW JAMES;HEAD JOHN CLIFFORD;ALEXANDER RIKKI PETER;LANGHAM BARRY JOHN;WARRELLOW GRAHAM JOHN;ARCHIBALD SARAH CATHERINE;LINSLEY JANEEN MARSHA |
发明人 |
NORMAN TIMOTHY JOHN;PORTER JOHN ROBERT;HUTCHINSON BRIAN WOODSIDE;RATCLIFFE ANDREW JAMES;HEAD JOHN CLIFFORD;ALEXANDER RIKKI PETER;LANGHAM BARRY JOHN;WARRELLOW GRAHAM JOHN;ARCHIBALD SARAH CATHERINE;LINSLEY JANEEN MARSHA |
分类号 |
A61K31/198;A61K31/223;A61K31/4375;A61K31/4409;A61K31/4436;A61K31/4545;A61K31/472;A61P1/04;A61P3/10;A61P11/06;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P19/08;A61P19/10;A61P21/00;A61P25/28;A61P29/00;A61P37/06;A61P43/00;C07C229/36;C07D213/81;C07D217/22;C07D409/12;C07D471/04;(IPC1-7):A61K31/44;A61K31/401;A61K31/40;A61K31/135 |
主分类号 |
A61K31/198 |
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