发明名称 |
IDENTIFICATION OF MODULATORS OF GPR41 OR GPR42 ACTIVITY |
摘要 |
This invention relates to a method for identification of an agent that modulates activity of G-protein coupled receptor 41 (GPR 41), or G-protein coupled receptor 42 (GPR 42) which method comprises: (i) contacting a test agent with GPR 41, GPR42 or a variant of either thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 41 or GPR 42 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 41 or GPR 42 activity. An agent identifiable by this method is provided for use in the treatment of dyslipidaemia, coronary heart disease, atheroselerosis, thrombosis or obesity, angina, chronic renal failure, peripheral vascular disease, stroke, type II diabetes or metabolic syndrome (syndrome X). |
申请公布号 |
WO0161359(A3) |
申请公布日期 |
2002.03.28 |
申请号 |
WO2001GB00684 |
申请日期 |
2001.02.19 |
申请人 |
GLAXO GROUP LIMITED;WISE, ALAN;BROWN, ANDREW, JAMES |
发明人 |
WISE, ALAN;BROWN, ANDREW, JAMES |
分类号 |
A61P3/04;A61P3/06;A61P3/10;G01N33/566 |
主分类号 |
A61P3/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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