| 摘要 |
The present invention provides a method for identification of an agent that modulates activity of G-protein coupled receptor 31 (GPR 31). The method comprises: (i) contacting a test agent with GPR 31 or a variant thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 31 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 31 activity. The invention also provides activators of GPR 31, inhibitors of lipolysis and GPR 31 polynucleotides which can be used in the treatment of dyslipidaemia, coronary heart disease, atheroscloresis, thrombosis or obesity, angina, chronic renal failure, peripheral vascular disease, stroke, type I diabetes or metabolic syndrome (syndrome X). |
