发明名称 |
MODIFICATION OF HEPATITIS B CORE ANTIGEN |
摘要 |
A protein is provided comprising hepatitis B core antigen (HBcAg) wherein one or more of the four arginine repeats has been deleted, said protein comprising the C-terminal cysteine of HBcAg. The deleted region may be replaced by an epitope from a protein other than HBcAg, in which case the HBcAg acts as a carrier to present the epitope to the immune system. The chimeric protein is useful in prophylactic and therapeutic vaccination of a host, for example against hepatitis B virus. |
申请公布号 |
WO0198333(A3) |
申请公布日期 |
2002.03.28 |
申请号 |
WO2001GB02817 |
申请日期 |
2001.06.22 |
申请人 |
CELLTECH PHARMACEUTICALS LIMITED;PAGE, MARK;LI, JING-LI;PUMPENS, PAUL;BORISOVA, GALINA |
发明人 |
PAGE, MARK;LI, JING-LI;PUMPENS, PAUL;BORISOVA, GALINA |
分类号 |
C12N15/09;A61K38/00;A61K39/29;A61K48/00;A61P1/16;A61P31/20;C07K14/02;C07K14/47;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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