| 摘要 |
A compound of formula (1) comprising a mono- or diester of an alpha, omega -dicarboxylic acid, wherein the alcohol moiety of the ester comprises a keratolytically active alcohol moiety of formula X wherein; n is in the range of 6 to 12; and m is in the range of 0 to 8; and R' is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl, OH, NHR'', CONHR'' and COOR''; and R'' is selected form the group consisting of alkyl, aryl, alkenyl, and benzyl; Y is selected form the group consisting of alkyl, aryl, alkenyl, benzyl and X; Provided that when m is 0, R' cannot be (CH3)2 -, para - (CH3)C-, meta - (CH3)3 C-, or ((CH3)3CCH2)2-. The compounds are useful for the treatment of dermatological disorders.
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