PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-.BETA.) INHIBITINGACTIVITY

摘要

Pyridine compounds of general formula (I) wherein -R1 represents, or in whic h R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C 1- 6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino , or -O-(CH2)n-R111 ; R2 represents hydrogen or halogen; R3 represents hydroge n, -CR31R32R33, or -NR34R35; R4 is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compou nd has an excellent anti-inflammatory activity, and other biological activity.< /SDOAB>