The invention concerns the use of a nucleic acid/cationic polymer complex, preferably polyethyleneimine (PEI) for preparing a composition for intraventricular stereotactic screening of stem cells of the brain for preparing a medicine for treating neurodegenerative and/or demyelinating diseases. The invention further concerns a method for obtaining an animal whereof the genome of stem cells of the brain are modified by using said complex. The invention also concerns a method for obtaining an animal for screening compounds designed to modify the disposition of stem cells of the brain.
申请公布号
WO0224231(A1)
申请公布日期
2002.03.28
申请号
WO2001FR02952
申请日期
2001.09.21
申请人
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;DEMENEIX, BARBARA;LEMKINE, GREGORY;LEVI, GIOVANNI