Novel genetic variants of the Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide (ADH7) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the ADH7 gene. Compositions and methods for haplotyping and/or genotyping the ADH7 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.