Endothelin converting enzymes and the amyloid betapeptide

摘要

The invention describes catabolism of Abeta by endothelin converting enzymes (ECEs). Methods of identifying compounds that upregulate ECEs are provided by the invention. Further provided by the invention are methods of regulating Abeta catabolism in a cell and methods of decreasing the amount of Abeta in a cell. The invention discloses methods of diagnosing an individual with AD and methods of treating such an individual. The invention further discloses methods of identifying compounds that have anti-hypertension activity but do not cause an increase in the level of Abeta. Further, the invention provides mutant ECE nucleic acids and mutant ECE polypeptides.