发明名称 |
Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
摘要 |
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
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申请公布号 |
US6361946(B1) |
申请公布日期 |
2002.03.26 |
申请号 |
US19990355700 |
申请日期 |
1999.11.05 |
申请人 |
LICENTIA LTD;LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
ALITALO KARI;JOUKOV VLADIMIR |
分类号 |
A01K67/027;A61K38/00;A61K38/22;A61K39/395;A61K48/00;A61P9/00;A61P17/02;A61P43/00;C07K14/475;C07K14/52;C07K16/22;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/18;C12P21/02;C12Q1/68;C12R1/91;(IPC1-7):C12Q1/68;C12P21/06;C12N1/20;C12N15/00;C07H21/02 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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地址 |
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